China (Mainland)
low price Artemisinin with high quality CAS NO.63968-64-9
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- Min.Order: 1 Kilogram
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1(31-50)Kilogram1(21-30)Kilogram2(11-20)Kilogram3(1-10)Kilogram
- Product Details
Keywords
- Artemisinin
- 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one,octahydro-3,6,9-tr
- ;octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10
Quick Details
- ProName: low price Artemisinin with high quali...
- CasNo: 63968-64-9
- Molecular Formula: C15H22O5
- Appearance: White Crystalline Powder
- Application: Active Pharmaceutical Ingredients;Misc...
- DeliveryTime: ASAP / Prompt upon the Payment terms
- PackAge: Customized
- Port: Qingdao,Shanghai, Tianjin
- ProductionCapacity: 100 Kilogram/Month
- Purity: 99%
- Storage: Cool and dry place
- Transportation: by sea, by air
- LimitNum: 1 Kilogram
- Plant of Origin: Natural
- Testing Method: HPLC
- Product Ecification: 99%
- Heavy Metal: 0.01
- Voluntary Standards: QB
- Mol File: 63968-64-9.mol
- Melting point: 156-157 °C(lit.)
- alpha: 76 o (c=0.5,MeOH)
- solubility: Soluble to 100mM in DMSO and to 75mM i...
Superiority
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.
At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.
Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.
Details
| Artemisinin Basic information |
| Artemisinin Chemical Properties |
| Melting point | 156-157 °C(lit.) |
| alpha | 76 º (c=0.5,MeOH) |
| refractive index | 75 ° (C=0.5, MeOH) |
| storage temp. | Store at +4°C |
| solubility | Soluble to 100mM in DMSO and to 75mM in ethanol |
| Merck | 14,817 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air. |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | KD4170000 |
| HS Code | 29322985 |
| MSDS Information |
| Provider | Language |
|---|---|
| (+)-Arteannuin | English |
| SigmaAldrich | English |
| Artemisinin Usage And Synthesis |
| Drugs for treatment of malaria |
Artemisinin is the drug for the treatment of malaria with the most excellent efficacy, being a kind of sesquiterpene lactone containing peroxide group extracted from the traditional Chinese medicine Artemisia annua. It is characterized with high efficiency, rapid efficacy, clearing summer-heat, clearing deficiency heat, protozoa-killing effect and low toxicity. Currently, the efficacy of the artemisinin-based combination therapy (ACT) for the treatment of malaria worldwide has reached over 90%. ACT has been already widely applied to the treatment of malaria in many countries around the world. It has a strong and rapid killing effect on the erythrocytic stage of plasmodium, being able to rapidly control the clinical seizures and symptoms. Meanwhile, it also has prominent efficacy in the treatment of chicken coccidiosis, Mycoplasma Suis, toxoplasmosis, weakness and fever, damp heat jaundice, tertian malaria, falciparum malaria, cerebral malaria and chloroquine malaria. Artemisinin was first successfully developed by Chinese scientists, being effective monomer originated from the folk malaria-treatment herbs Artemisia annua. China is one of the major resource countries for the growth of such plants. The demands for research and development originated from the Vietnam War in 1960s when Malaria parasites had been resistant to special drug chloroquine at that time. In Vietnam War, many soldiers are not killed in the war, but instead died of malaria. Because of the presence of artemisinin resistance in the border areas of Cambodia and Thailand, the World Health Organization advocates the use of combinations rather than monomeric formulation. In this environment, the world's first artemisinin-based compound antimalarial drug-compound artemether has been successfully developed in China. However, due to the lack of attention on the importance of intellectual property of Chinese pharmaceutical companies, currently in the world, only Novartis Company has the authority of foreign selling of artemether compound that has been recognized by the World Health Organization. The Novartis Company has offered the drug to the WHO at the cost price, wining the wide acclaim from international community. However, in this trade war, China can only play a role of major drug producing countries. |
| Chemical properties | It appears as colorless needle crystal with a melting point being156-157 °C. It is easily soluble in chloroform, acetone, ethyl acetate and benzene, being soluble in methanol, ethanol and insoluble in water. |
| Uses |
Artemisia annua is used as antimalarial drugs. Clinical application has shown that artemisinin and its derivatives have special effects on treating the malaria and falciparum malaria, especially artemisinin which has stronger killing effect on Plasmodium falciparum intracellular phorozoon than other artemisinin drugs, characterized by high efficiency, rapid efficacy, low toxicity and no cross-resistance with chloroquine, etc. It can be not only used for treatment, but also for emergency treatment. It is applicable to a variety of malaria such as falciparum malaria, vivax malaria, anti-chloroquine malaria and cerebral malaria, including dangerous type. The most notable drug is dihydroartemisinin and its tablets. This drug has its antimalarial effect be 10 times as strong as artemisinin with the recurrence rate of only 1.95%, thus having been rated as China's top ten scientific and technological achievements in 1992. Artemisinin and its derivatives not only are excellent antimalarial drugs, but also have potentially attractive prospect in the treatment of other diseases. Animal experiments have found that artemisinin treatment of Clonorchis sinensis can achieve a rate of pest control being up to 100%; treatment of animal schistosomiasis can achieve a pest control rate of 33.8-99.3%. Application of artemisinin treatment of discoid lupus erythematosus can achieve a total effective rate of 90%. Its efficacy in the treatment of dengue fever is significantly better than morphine biguanide and other western medicines. Immunologists have also found that artemisinin can significantly improve the lymphocyte transformation rate and enhance the immune function of antibodies. People haven’t found toxic effect of this product on the heart, liver and kidney. People haven’t observed any significant side effects in clinical practice. |
| Production method | It can be extracted from the leaves of Artemisia annua L. (Compositae). In addition to artemisinin, China also produces both artemether and sodium artemisinin. |
| Category | Toxic substances |
| Toxic grading | Poisoning |
| Acute toxicity | Intraperitoneal-rat LD50: 2571 mg/kg; Abdominal-mouse LD50: 1558 mg/kg |