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Home > Products >  competitive price 2-Bromo-2-nitro-1,3-propanediol 52-51-7

competitive price 2-Bromo-2-nitro-1,3-propanediol 52-51-7 CAS NO.52-51-7

  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,Other
  • Product Details

Keywords

  • 52-51-7
  • 2-Bromo-2-nitro-1,3-propanediol
  • C3H6BrNO4

Quick Details

  • ProName: competitive price 2-Bromo-2-nitro-1,3-...
  • CasNo: 52-51-7
  • Molecular Formula: C3H6BrNO4
  • Appearance: Powder
  • Application: Preservative in cosmetics and toiletri...
  • DeliveryTime: within 3 days
  • PackAge: as customer's request
  • Port: Shanghai/Qingdao
  • ProductionCapacity: 1 Kilogram/Day
  • Purity: 97%-99%
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: By sea/car
  • LimitNum: 1 Kilogram

Superiority

 

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 
Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.
 
At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.
 
Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.
 
Coreychem
Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade.
 
 
Innovative
Henan Coreychem is committed to continuously explore new compound synthesis technology in recent years,we were on enzyme catalysis, catalytic metal complexes in the total synthesis was tested and achieved good results: S.lycopersicum (+) - Aszonalenin (+) - Citrinadin B Total Synthesis of ( − )-Brevicompanine B by Ir-Catalyzed Total Synthesis of (+)-Citrinadin B
 

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

 

Details

2-Bromo-2-nitro-1,3-propanediol Basic information
Product Name: 2-Bromo-2-nitro-1,3-propanediol
Synonyms: Bronopol 1g [52-51-7];Broken Ball;2-BroMo-2-nitropropane-1;3-diol (Bronopol);Bronopol(2-BroMo-2-nitro-1,3-propanedio1);2-BroMo-2-nitro-1,3-propanediol, 98% 25GR;Bronopol API;BNPK
CAS: 52-51-7
MF: C3H6BrNO4
MW: 199.99
EINECS: 200-143-0
Product Categories: Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Polyols;Antibacterial agent;-;Antiseptic-water treatment-bactericide-Bronopol;Food additive;CHEMICAL;Propanes/propenes;FUNGICIDE;Biocide;water treatment agent
Mol File: 52-51-7.mol
2-Bromo-2-nitro-1,3-propanediol Structure
 
2-Bromo-2-nitro-1,3-propanediol Chemical Properties
Melting point  130-133 °C(lit.)
density  2.0002 (rough estimate)
refractive index  1.6200 (estimate)
Fp  167°C
solubility  H2O: soluble100mg/mL, clear, colorless to faintly yellow
form  Crystals or Crystalline Powder
color  White to yellow
Water Solubility  25 g/100 mL (22 ºC)
Merck  14,1447
BRN  1705868
Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture.
CAS DataBase Reference 52-51-7(CAS DataBase Reference)
NIST Chemistry Reference Bronopol(52-51-7)
EPA Substance Registry System 1,3-Propanediol, 2-bromo-2-nitro-(52-51-7)
 
Safety Information
Hazard Codes  Xn,N
Risk Statements  21/22-37/38-41-50
Safety Statements  26-37/39-61-36/37/39
RIDADR  UN 3241 4.1/PG 3
WGK Germany  2
RTECS  TY3385000
4.2-8-9-21
TSCA  Yes
HazardClass  4.1
PackingGroup  III
HS Code  29055999
Hazardous Substances Data 52-51-7(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 350, 400 orally (Croshaw)
MSDS Information
Provider Language
Bronopol English
ACROS English
SigmaAldrich English
ALFA English
 
2-Bromo-2-nitro-1,3-propanediol Usage And Synthesis
Chemical Properties off-white crystalline powder
Chemical Properties Bronopol is a white or almost white crystalline powder; odorless or with a faint characteristic odor.
Uses Preservative in cosmetics and toiletries. Antiseptic.
Production Methods Bronopol is synthesized by the reaction of nitromethane with paraformaldehyde in an alkaline environment, followed by bromination. After crystallization, bronopol powder may be milled to produce a powder of the required fineness.
General Description White crystals. Ignite easily and burn readily. May detonate under strong shock. Decomposes when heated, evolving toxic gases. Toxic by skin absorption, inhalation or ingestion.
Air & Water Reactions Highly flammable. Water soluble.
Reactivity Profile Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and acid anhydrides. 2-Bromo-2-nitro-1,3-propanediol is also incompatible with sulfhydryl compounds or with aluminum or iron containers (it is stable in contact with tin or stainless steel).
Hazard Toxic by all routes of exposure; skin irritant.
Health Hazard Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Pharmaceutical Applications Bronopol 0.01–0.1% w/v is used as an antimicrobial preservative either alone or in combination with other preservatives in topical pharmaceutical formulations, cosmetics, and toiletries; the usual concentration is 0.02% w/v.
Contact allergens Bronopol is a preservative sometimes considered as a formaldehyde releaser. It was reported to be an allergen in cosmetics, cleaning agents, dairy workers, and a lubricant jelly used for ultrasound examination.
Safety Profile Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. An eye and human skin irritant. An antiseptic. When heated to decomposition it emits very toxic fumes of NOx, and Br-.
Safety Bronopol is used widely in topical pharmaceutical formulations and cosmetics as an antimicrobial preservative.
Although bronopol has been reported to cause both irritant and hypersensitivity adverse reactions following topical use, it is generally regarded as a nonirritant and nonsensitizing material at concentrations up to 0.1% w/v. At a concentration of 0.02% w/v, bronopol is frequently used as a preservative in ‘hypoallergenic’ formulations.
Animal toxicity studies have shown no evidence of phototoxicity or tumor occurrence when bronopol is applied to rodents topically or administered orally; and there is no in vitro or in vivo evidence of mutagenicity; this is despite the demonstrated potential of bronopol to liberate nitrite on decomposition, which in the presence of certain amines may generate nitrosamines. Formation of nitrosamines in formulations containing amines may be reduced by limiting the concentration of bronopol to 0.01% w/v and including an antioxidant such as 0.2% w/v alpha tocopherol or 0.05% w/v butylated hydroxytoluene;(14) other inhibitor systems may also be appropriate.
LD50 (dog, oral): 250 mg/kg
LD50 (mouse, IP): 15.5 mg/kg
LD50 (mouse, IV): 48 mg/kg
LD50 (mouse, oral): 270 mg/kg
LD50 (mouse, SC): 116 mg/kg
LD50 (mouse, skin): 4.75 g/kg
LD50 (rat, IP): 26 mg/kg
LD50 (rat, IV): 37.4 mg/kg
LD50 (rat, oral): 180 mg/kg
LD50 (rat, SC): 170 mg/kg
LD50 (rat, skin): 1.6 g/kg
storage Bronopol is stable and its antimicrobial activity is practically unaffected when stored as a solid at room temperature and ambient relative humidity for up to 2 years.
The pH of a 1.0% w/v aqueous solution is 5.0–6.0 and falls slowly during storage; solutions are more stable in acid conditions.
Microbiological assay results indicate longer half-lives than those obtained by HPLC and thus suggest that degradation products may contribute to antimicrobial activity. Formaldehyde and nitrites are among the decomposition products, but formaldehyde arises in such low concentrations that its antimicrobial effect is not likely to be significant. On exposure to light, especially under alkaline conditions, solutions become yellow or brown-colored but the degree of discoloration does not directly correlate with loss of antimicrobial activity.
The bulk material should be stored in a well-closed, nonaluminum container protected from light, in a cool, dry place.
Incompatibilities Sulfhydryl compounds cause significant reductions in the activity of bronopol, and cysteine hydrochloride may be used as the deactivating agent in preservative efficacy tests; lecithin/polysorbate combinations are unsuitable for this purpose. Bronopol is incompatible with sodium thiosulfate, with sodium metabisulfite, and with amine oxide or protein hydrolysate surfactants. Owing to an incompatibility with aluminum, the use of aluminum in the packaging of products that contain bronopol should be avoided.
Regulatory Status Included in topical pharmaceutical formulations licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
 
2-Bromo-2-nitro-1,3-propanediol Preparation Products And Raw materials
Raw materials Methanol-->Diethyl ether-->Bromine-->Potassium hydroxide -->Formaldehyde-->Sodium methanolate-->Nitromethane-->Dichloroethane-->1,3-Propanediol

 

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