- Product Details
Keywords
- 52-51-7
- 2-Bromo-2-nitro-1,3-propanediol
- C3H6BrNO4
Quick Details
- ProName: competitive price 2-Bromo-2-nitro-1,3-...
- CasNo: 52-51-7
- Molecular Formula: C3H6BrNO4
- Appearance: Powder
- Application: Preservative in cosmetics and toiletri...
- DeliveryTime: within 3 days
- PackAge: as customer's request
- Port: Shanghai/Qingdao
- ProductionCapacity: 1 Kilogram/Day
- Purity: 97%-99%
- Storage: Store in dry, dark and ventilated plac...
- Transportation: By sea/car
- LimitNum: 1 Kilogram
Superiority
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Details
2-Bromo-2-nitro-1,3-propanediol Basic information |
Product Name: | 2-Bromo-2-nitro-1,3-propanediol |
Synonyms: | Bronopol 1g [52-51-7];Broken Ball;2-BroMo-2-nitropropane-1;3-diol (Bronopol);Bronopol(2-BroMo-2-nitro-1,3-propanedio1);2-BroMo-2-nitro-1,3-propanediol, 98% 25GR;Bronopol API;BNPK |
CAS: | 52-51-7 |
MF: | C3H6BrNO4 |
MW: | 199.99 |
EINECS: | 200-143-0 |
Product Categories: | Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Polyols;Antibacterial agent;-;Antiseptic-water treatment-bactericide-Bronopol;Food additive;CHEMICAL;Propanes/propenes;FUNGICIDE;Biocide;water treatment agent |
Mol File: | 52-51-7.mol |
|
2-Bromo-2-nitro-1,3-propanediol Chemical Properties |
Melting point | 130-133 °C(lit.) |
density | 2.0002 (rough estimate) |
refractive index | 1.6200 (estimate) |
Fp | 167°C |
solubility | H2O: soluble100mg/mL, clear, colorless to faintly yellow |
form | Crystals or Crystalline Powder |
color | White to yellow |
Water Solubility | 25 g/100 mL (22 ºC) |
Merck | 14,1447 |
BRN | 1705868 |
Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture. |
CAS DataBase Reference | 52-51-7(CAS DataBase Reference) |
NIST Chemistry Reference | Bronopol(52-51-7) |
EPA Substance Registry System | 1,3-Propanediol, 2-bromo-2-nitro-(52-51-7) |
Safety Information |
Hazard Codes | Xn,N |
Risk Statements | 21/22-37/38-41-50 |
Safety Statements | 26-37/39-61-36/37/39 |
RIDADR | UN 3241 4.1/PG 3 |
WGK Germany | 2 |
RTECS | TY3385000 |
F | 4.2-8-9-21 |
TSCA | Yes |
HazardClass | 4.1 |
PackingGroup | III |
HS Code | 29055999 |
Hazardous Substances Data | 52-51-7(Hazardous Substances Data) |
Toxicity | LD50 in mice, rats (mg/kg): 350, 400 orally (Croshaw) |
MSDS Information |
Provider | Language |
---|---|
Bronopol | English |
ACROS | English |
SigmaAldrich | English |
ALFA | English |
2-Bromo-2-nitro-1,3-propanediol Usage And Synthesis |
Chemical Properties | off-white crystalline powder |
Chemical Properties | Bronopol is a white or almost white crystalline powder; odorless or with a faint characteristic odor. |
Uses | Preservative in cosmetics and toiletries. Antiseptic. |
Production Methods | Bronopol is synthesized by the reaction of nitromethane with paraformaldehyde in an alkaline environment, followed by bromination. After crystallization, bronopol powder may be milled to produce a powder of the required fineness. |
General Description | White crystals. Ignite easily and burn readily. May detonate under strong shock. Decomposes when heated, evolving toxic gases. Toxic by skin absorption, inhalation or ingestion. |
Air & Water Reactions | Highly flammable. Water soluble. |
Reactivity Profile | Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and acid anhydrides. 2-Bromo-2-nitro-1,3-propanediol is also incompatible with sulfhydryl compounds or with aluminum or iron containers (it is stable in contact with tin or stainless steel). |
Hazard | Toxic by all routes of exposure; skin irritant. |
Health Hazard | Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. |
Fire Hazard | Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished. |
Pharmaceutical Applications | Bronopol 0.01–0.1% w/v is used as an antimicrobial preservative either alone or in combination with other preservatives in topical pharmaceutical formulations, cosmetics, and toiletries; the usual concentration is 0.02% w/v. |
Contact allergens | Bronopol is a preservative sometimes considered as a formaldehyde releaser. It was reported to be an allergen in cosmetics, cleaning agents, dairy workers, and a lubricant jelly used for ultrasound examination. |
Safety Profile | Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. An eye and human skin irritant. An antiseptic. When heated to decomposition it emits very toxic fumes of NOx, and Br-. |
Safety |
Bronopol is used widely in topical pharmaceutical formulations and cosmetics as an antimicrobial preservative. Although bronopol has been reported to cause both irritant and hypersensitivity adverse reactions following topical use, it is generally regarded as a nonirritant and nonsensitizing material at concentrations up to 0.1% w/v. At a concentration of 0.02% w/v, bronopol is frequently used as a preservative in ‘hypoallergenic’ formulations. Animal toxicity studies have shown no evidence of phototoxicity or tumor occurrence when bronopol is applied to rodents topically or administered orally; and there is no in vitro or in vivo evidence of mutagenicity; this is despite the demonstrated potential of bronopol to liberate nitrite on decomposition, which in the presence of certain amines may generate nitrosamines. Formation of nitrosamines in formulations containing amines may be reduced by limiting the concentration of bronopol to 0.01% w/v and including an antioxidant such as 0.2% w/v alpha tocopherol or 0.05% w/v butylated hydroxytoluene;(14) other inhibitor systems may also be appropriate. LD50 (dog, oral): 250 mg/kg LD50 (mouse, IP): 15.5 mg/kg LD50 (mouse, IV): 48 mg/kg LD50 (mouse, oral): 270 mg/kg LD50 (mouse, SC): 116 mg/kg LD50 (mouse, skin): 4.75 g/kg LD50 (rat, IP): 26 mg/kg LD50 (rat, IV): 37.4 mg/kg LD50 (rat, oral): 180 mg/kg LD50 (rat, SC): 170 mg/kg LD50 (rat, skin): 1.6 g/kg |
storage |
Bronopol is stable and its antimicrobial activity is practically unaffected when stored as a solid at room temperature and ambient relative humidity for up to 2 years. The pH of a 1.0% w/v aqueous solution is 5.0–6.0 and falls slowly during storage; solutions are more stable in acid conditions. Microbiological assay results indicate longer half-lives than those obtained by HPLC and thus suggest that degradation products may contribute to antimicrobial activity. Formaldehyde and nitrites are among the decomposition products, but formaldehyde arises in such low concentrations that its antimicrobial effect is not likely to be significant. On exposure to light, especially under alkaline conditions, solutions become yellow or brown-colored but the degree of discoloration does not directly correlate with loss of antimicrobial activity. The bulk material should be stored in a well-closed, nonaluminum container protected from light, in a cool, dry place. |
Incompatibilities | Sulfhydryl compounds cause significant reductions in the activity of bronopol, and cysteine hydrochloride may be used as the deactivating agent in preservative efficacy tests; lecithin/polysorbate combinations are unsuitable for this purpose. Bronopol is incompatible with sodium thiosulfate, with sodium metabisulfite, and with amine oxide or protein hydrolysate surfactants. Owing to an incompatibility with aluminum, the use of aluminum in the packaging of products that contain bronopol should be avoided. |
Regulatory Status | Included in topical pharmaceutical formulations licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
2-Bromo-2-nitro-1,3-propanediol Preparation Products And Raw materials |
Raw materials | Methanol-->Diethyl ether-->Bromine-->Potassium hydroxide -->Formaldehyde-->Sodium methanolate-->Nitromethane-->Dichloroethane-->1,3-Propanediol |