China (Mainland)
Naringenin CAS NO.480-41-1
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- Min.Order: 1 Kilogram
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- Available Specifications:
98(0-25)Kilogram98(1-100)Kilogram
- Product Details
Keywords
- Coreychem Important product
- Advanced and completed testing facilities
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Quick Details
- ProName: Naringenin
- CasNo: 480-41-1
- Molecular Formula: C15H12O5
- Appearance: ask
- Application: intermediates
- DeliveryTime: Within 3 days after payment
- PackAge: foil aluminium bag/vacuum packing
- Port: shanghai
- ProductionCapacity: 130 Kilogram/Week
- Purity: 85.0-99.8%
- Storage: Keep in dry and cool condition
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- Melting Point: 247-254oC
- Boiling Point: 577.5oC at 760mmHg
- Density: 1.485g/cm3
- Storage Temp: Store in a cool
- Flash Point: dry place. Store in a tightly closed c...
- Appearance: 224.7oC
- Refractive Index: beige-brown powder
- Safety Statements: 1.692
- WGK Germany: S26-S37/39
- Risk Statements: 3
Superiority
Product Name: Naringenin
Synonyms: naringenine;naringetol;4’,5,7-trihydroxy-flavanon;S-Dihydrogenistein;NSC 34875;NSC 11855;(S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-ben;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (S)-
CAS: 480-41-1
MF: C15H12O5
MW: 272.25
EINECS: 207-550-2
Product Categories: -;Natural Plant Extract;Flavanones;Inhibitors;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;CITRIMORE
Mol File: 480-41-1.mol
Naringenin Structure
Naringenin Chemical Properties
Melting point 247-250 °C(lit.)
Boiling point 335.31°C (rough estimate)
density 1.2066 (rough estimate)
refractive index 1.6000 (estimate)
FEMA 4797 | (+/-)-NARINGENIN
storage temp. -20°C Freezer
form Powder
color Beige-brown
CAS DataBase Reference 480-41-1(CAS DataBase Reference)
EPA Substance Registry System 4H-1-Benzopyran- 4-one, 2,3-dihydro-5,7-dihydroxy- 2-(4-hydroxyphenyl)-, (2S)-(480-41-1)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36-37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29329990
MSDS Information
Provider Language
5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one English
SigmaAldrich English
ACROS English
ALFA English
Naringenin Usage And Synthesis
Pharmacological effects Naringenin is the aglycone of naringin, it belongs to dihydro-flavonoids, at room temperature it is a white needle crystal(methanol), soluble in alcohol, ether and benzene, almost insoluble in water. In HCl-Mg powder reaction,it is cherry red ,in sodium borohydride reaction it is red purple, in molish reaction,it is negative. In the nature, it is mainly from the Rosaceae cherry (Prunus yedoensis Mate.) bud,and sumac plants (Amacardi-um occidentale L.) fruits’ core-shell.
Nucleus structure is similar among flavonoids, most of the components do not have ideal fat-soluble and water-soluble abilities, the bioavailability is low. By modifying its structure, the introduction of strongly fat-soluble or water-soluble groups can increase its fat-soluble or water-soluble abilities, thus improving the bioavailability. The structure modification includes alkylation, acylation, sulfonation,glycosidation of hydroxyl groups and the formation of the metal complex.
The effects of naringenin including: anti-bacterial, anti-inflammatory, antioxidant, cough expectorant,decreasing blood fat, anti-cancer and anti-tumor, antispasmodic, scavenging free radicals, prevention and treatment of liver disease, inhibition of platelet aggregation, anti-atherosclerosis and others , which can be widely used in medicine, food and other fields.
1. Antibacterial: it has a strong antibacterial effect on Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, and Salmonella typhi. Naringenin also has effect on fungi , 1000ppm is sprayed onto the rice, blast fungus infection can be reduced 40-90%,and it is not toxic to livestock and humans.
2. Anti-inflammatory: intraperitoneal injection of 20mg/kg per day for rats can inhibit the inflammatory process which caused by wool ball implantation.
3. Anticancer: it displays action in L1210 leukemia and sarcomas in rats.
4. Antispasmodic and gallbladder: among the flavonoids,it has stronger effects. Naringenin has a strong effect on increasing bile secretion in experimental animals.
Application It has anti-bacterial, anti-inflammatory, anti-cancer, antispasmodic and choleretic effects.
Chemical Properties beige-brown powder
Uses The aglucon of Naringin. Inhibitory mechanism of Naringenin against carcinogenic acrylamide formation and nonenzymic browning in Maillard model reactions
Uses antiulcer, antioxidant, immunomodulator, cholesterol lowering
Purification Methods Crystallise it from EtOH or aqueous EtOH. It has UV: at 290nm (EtOH). The S(-)-enantiomer (natural form) has m 255-256o (from EtOH) and [] D -28.0o (c 2, EtOH), [] D -35.2o (c 1, pyridine).
Details
Hazard Codes:Xn:Harmful
CAS No.:480-41-1
Synonyms:View More5,7,4'-trihydroxyflavanone; Derivative of; rac-naringenin; salipurpol; 4',5,7-trihydroxyflavanone; salipurol; naringenine; naringetol;
Formula:C15H12O5
Exact Mass:272.06800
Molecular Weight:272.25300
PSA:86.99000
LogP:2.50990
| Naringenin | |
| CAS No.: | 480-41-1 |
|---|---|
| Synonyms: |
View More
|
| Formula: | C15H12O5 |
| Exact Mass: | 272.06800 |
| Molecular Weight: | 272.25300 |
| PSA: | 86.99000 |
| LogP: | 2.50990 |
|
Properties
|
|
| Melting Point: | 247-254oC |
|---|---|
| Boiling Point: | 577.5oC at 760mmHg |
| Density: | 1.485g/cm3 |
| Storage Temp: | Store in a cool, dry place. Store in a tightly closed container. |
| Flash Point: | 224.7oC |
| Appearance: | beige-brown powder |
| Refractive Index: | 1.692 |
|
Safety Info
|
|
| Safety Statements: | S26-S37/39 |
|---|---|
| WGK Germany: | 3 |
| Risk Statements: | R22;R36/37/38 |
| Hazard Codes: | Xn:Harmful |
Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates fine chemicals custom synthesis, scale-up production and rare chemicals trade. We have experienced research staff, strong technical force, well-equipped machine, and considerate marketing team service, with a strict customer intellectual property security system, we are already become good partner of customers from difficult and complex chemical and biological chemical field. Our high quality & low price and effective services shortened new product development cycle,reduced the development and production cost for numerous partners.
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