China (Mainland)
Aicar CAS NO.2627-69-2
- FOB Price: USD: 1.00-1.00 /Metric Ton Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: T/T,Other
- Available Specifications:
98(0-25)Metric Ton98(1-100)Metric Ton
- Product Details
Keywords
- Coreychem Important product
- Advanced and completed testing facilities
- High Cost-Effective
Quick Details
- ProName: Aicar
- CasNo: 2627-69-2
- Molecular Formula: C9H14N4O5
- Appearance: ask
- Application: intermediates
- DeliveryTime: Within 3 days after payment
- PackAge: foil aluminium bag/vacuum packing
- Port: shanghai
- ProductionCapacity: 130 Kilogram/Week
- Purity: 85.0-99.8%
- Storage: Keep in dry and cool condition
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- Melting Point: 214-215oC
- Boiling Point: 726.3oC at 760 mmHg
- Density: 2.06 g/cm3
- Storage Temp: -20oC
- Flash Point: 393.1oC
- Appearance: Solid
- Vapor Pressure: 3.83E-22mmHg at 25°C
- Refractive Index: 1.821
- Safety Statements: 26-36
- WGK Germany: 3
Superiority
| Product Name: | AICAR |
| Synonyms: | ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;1-Deoxy-1-[(4-carbamoyl-5-amino-1H-imidazole)-1-yl]-β-D-ribofuranose;1-β-D-Ribofuranosyl-5-amino-1H-imidazole-4-carboxamide;5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide;AICA-β-D-Riboside |
| CAS: | 2627-69-2 |
| MF: | C9H14N4O5 |
| MW: | 258.23 |
| EINECS: | 220-097-5 |
| Product Categories: | ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;PI3K;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Akt;mTOR |
| Mol File: | 2627-69-2.mol |
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| AICAR Chemical Properties |
| Melting point | 214-215 °C |
| storage temp. | −20°C |
| solubility | H2O: >10 mg/mL |
| form | powder |
| color | tan |
| Water Solubility | Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml |
| λmax | 265nm(NaOH)(lit.) |
| Merck | 14,16 |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| CAS DataBase Reference | 2627-69-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2) |
| Safety Information |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-61 |
| Safety Statements | 26-36-45-53 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29349990 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| AICAR Usage And Synthesis |
| adenosine regulating agents |
Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death. |
| Chemical Properties | Solid |
| Uses | glucose uptake stimulant; AMPK activator |
| Uses | AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. |
| Definition | ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects. |
| Biological Activity | Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. |
Details
Risk Statements:R36/37/38
Hazard Codes:Xi: Irritant;
CAS No.:2627-69-2
Synonyms:View MoreArasine; Acadesine,AICA; AICA-RIBOSIDE; GP 1-110; Acadesine; AMPK; AIC-Riboside; 5-amino-4-imidazole carboxamide ribonucleoside; ACADESINE; Z-RIBOSIDE;
Formula:C9H14N4O5
Exact Mass:258.09600
Molecular Weight:258.23100
PSA:156.85000
LogP:-1.54280
| Aicar | |
| CAS No.: | 2627-69-2 |
|---|---|
| Synonyms: | |
| Formula: | C9H14N4O5 |
| Exact Mass: | 258.09600 |
| Molecular Weight: | 258.23100 |
| PSA: | 156.85000 |
| LogP: | -1.54280 |
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Properties
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| Melting Point: | 214-215oC |
|---|---|
| Boiling Point: | 726.3oC at 760 mmHg |
| Density: | 2.06 g/cm3 |
| Storage Temp: | -20oC |
| Flash Point: | 393.1oC |
| Appearance: | Solid |
| Vapor Pressure: | 3.83E-22mmHg at 25C |
| Refractive Index: | 1.821 |
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Safety Info
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| Safety Statements: | 26-36 |
|---|---|
| WGK Germany: | 3 |
| Risk Statements: | R36/37/38 |
| Hazard Codes: | Xi: Irritant; |
Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates fine chemicals custom synthesis, scale-up production and rare chemicals trade. We have experienced research staff, strong technical force, well-equipped machine, and considerate marketing team service, with a strict customer intellectual property security system, we are already become good partner of customers from difficult and complex chemical and biological chemical field. Our high quality & low price and effective services shortened new product development cycle,reduced the development and production cost for numerous partners.
The company has completed numerous domestic and overseas famous pharmaceutical, chemical, biological and other large and medium-sized company R&D outsourcing services, synthesis process development and optimization services, chemical intermediates customized service, special chemical processing and production services, etc., We hope to become continuous mutually beneficial partnership with you, to create a better business opportunities together.
Service Scope:
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