China (Mainland)
4-hydroxyphenylacetic Acid CAS NO.156-38-7
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- Product Details
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Quick Details
- ProName: 4-hydroxyphenylacetic Acid
- CasNo: 156-38-7
- Molecular Formula: C8H8O3
- Appearance: ask
- Application: intermediates
- DeliveryTime: Within 3 days after payment
- PackAge: foil aluminium bag/vacuum packing
- Port: shanghai
- ProductionCapacity: 130 Kilogram/Week
- Purity: 85.0-99.8%
- Storage: Keep in dry and cool condition
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- Melting Point: 147-152oC
- Boiling Point: 346.6oC at 760 mmHg
- Density: 1.319 g/cm3
- Storage Temp: Store in a tightly closed container. S...
- Flash Point: dry
- Stability: well-ventil
- Appearance: 177.6oC
- Vapor Pressure: Stable at room temperature in closed c...
- RTECS: white or light yellow crystalline powd...
- Safety Statements: 2.15E-05mmHg at 25°C
Superiority
Product Name: 4-Hydroxyphenylacetic acid
Synonyms: 4-hydrophenylacetic acid;Atenolol Impurity (4-Hydroxyphenylacetic;Atenolol Impurity K;4-hydroxy-benzeneaceticaci;4-hydroxybenzeneaceticacid;4-hydroxyphenylethanoicacid;4-Hydroxyphenylacetic acid,98%;HYDROXYPHENYLACETIC ACID, 4-(RG)
CAS: 156-38-7
MF: C8H8O3
MW: 152.15
EINECS: 205-851-3
Product Categories: -;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical;alcohol| carboxylic acid;Aromatic Phenylacetic Acids and Derivatives;C8Fluorescent Probes, Labels, Particles and Stains;Other Fluorescent Labels;Carbonyl Compounds;Carboxylic Acids;Fluorescent Labels
Mol File: 156-38-7.mol
4-Hydroxyphenylacetic acid Structure
4-Hydroxyphenylacetic acid Chemical Properties
Melting point 148-151 °C(lit.)
Boiling point 234.6°C (rough estimate)
density 1.2143 (rough estimate)
refractive index 1.4945 (estimate)
storage temp. Store below +30°C.
solubility 50g/l
form Crystalline Powder
color White to cream or light tan
PH 2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN 1448766
CAS DataBase Reference 156-38-7(CAS DataBase Reference)
NIST Chemistry Reference Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry System Benzeneacetic acid, 4-hydroxy-(156-38-7)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 3
RTECS AI2680000
Hazard Note Irritant
TSCA Yes
HS Code 29182990
MSDS Information
Provider Language
4-Hydroxyphenylacetic acid English
ACROS English
SigmaAldrich English
ALFA English
4-Hydroxyphenylacetic acid Usage And Synthesis
Description 4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.
Referrence
Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115.
Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.
Chemical Properties white to cream or light tan crystalline powder
Uses A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
Definition ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
Purification Methods Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]
4-Hydroxyphenylacetic acid Preparation Products And Raw materials
Raw materials Phenol-->Glyoxal-->Glyoxylic acid-->4-Aminophenylacetic acid
Preparation Products 2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate-->Cefprozil hydrate-->4-Hydroxyphenylacetamide-->4-METHOXYPHENYLACETYL CHLORIDE-->Camostat-->Isobutyl 4-hydroxybenzoate-->P-TOLYL-ACETYL CHLORIDE-->Ethyl 4-hydroxyphenylacetate-->Methyl 4-hydroxyphenylacetate-->Bufexamac
Details
HS Code:2918290000
WGK Germany:3
Risk Statements:R36/37/38
Hazard Codes:Xi:Irritant
CAS No.:156-38-7
Synonyms:2-(4-hydroxyphenyl)acetic acid;
Formula:C8H8O3
Exact Mass:152.04700
Molecular Weight:152.14700
PSA:57.53000
LogP:1.01930
| 4-hydroxyphenylacetic Acid | |
| CAS No.: | 156-38-7 |
|---|---|
| Synonyms: | |
| Formula: | C8H8O3 |
| Exact Mass: | 152.04700 |
| Molecular Weight: | 152.14700 |
| PSA: | 57.53000 |
| LogP: | 1.01930 |
|
Properties
|
|
| Melting Point: | 147-152oC |
|---|---|
| Boiling Point: | 346.6oC at 760 mmHg |
| Density: | 1.319 g/cm3 |
| Storage Temp: | Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. |
| Flash Point: | 177.6oC |
| Stability: | Stable at room temperature in closed containers under normal storage and handling conditions. |
| Appearance: | white or light yellow crystalline powder |
| Vapor Pressure: | 2.15E-05mmHg at 25C |
|
Safety Info
|
|
| RTECS: | AI2680000 |
|---|---|
| Safety Statements: | S24/25 |
| HS Code: | 2918290000 |
| WGK Germany: | 3 |
| Risk Statements: | R36/37/38 |
| Hazard Codes: | Xi:Irritant |
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