α-Lipoic Acid CAS NO.1077-28-7

 

Product Name: α-Lipoic Acid

Synonyms: （±）-1,2-Dithiolane-3-valeric Acid [Thioctic Acid];Alpha Lipoic Acid Thioctic acid in stock GMP Factory;α-Lipoic Acid - CAS 1077-28-7 - Calbiochem;THIOCTIC ACID;(+-)-2-dithiolane-3-pentanoicacid;(+-)-2-dithiolane-3-valericacid;(+/-)-2-dithiolane-3-pentanoicacid;1,2-Dithiolane-3-pentanoicacid,(+-)-(9CI)

CAS: 1077-28-7

MF: C8H14O2S2

MW: 206.33

EINECS: 214-071-2

Product Categories: -;Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives;Substrates;Antioxidant;Biochemistry;Nutritional Supplements;Biochemics;Heterocycles;Sulfur & Selenium Compounds;Food & Flavor Additives;Miscellaneous Compounds;Inhibitors;Pharmaceutical intermediates

Mol File: 1077-28-7.mol

α-Lipoic Acid Structure

α-Lipoic Acid Chemical Properties

Melting point 60-62 °C

Boiling point 160-165 °C(lit.)

density 1.2888 (rough estimate)

refractive index 1.5200 (estimate)

Fp 160-165°C

storage temp. 2-8°C

solubility ethanol: 50 mg/mL

form Crystals or Crystalline Powder

color Yellow

Water Solubility 0.9 g/L (20 ºC)

Merck 14,9326

BRN 81853

Stability: Stable. Incompatible with strong oxidizing agents.

InChIKey AGBQKNBQESQNJD-UHFFFAOYSA-N

CAS DataBase Reference 1077-28-7(CAS DataBase Reference)

NIST Chemistry Reference Dl-thioctic acid(1077-28-7)

Safety Information

Hazard Codes Xn

Risk Statements 22-20/21/22

Safety Statements 37/39-26-24/25-36-36/37/39

WGK Germany 3

RTECS JP1192000

HS Code 29349990

MSDS Information

Provider Language

5-(Dithiolan-3-yl)valeric acid English

SigmaAldrich English

ACROS English

ALFA English

α-Lipoic Acid Usage And Synthesis

Chemical Properties Light-Yellow Solid

Uses thioctic acid is also known as alpha lipoic acid. It is an anti-oxidant.

Uses A fat-metabolism stimulator

Brand name Liposan;Thioactacid.

Pharmaceutical Applications Lipoic acid(ALA), also known as α-lipoic acid (alpha-lipoic acid) or thioctic acid, has the formula C8H14S2O2 and systematic name 5-(1,2-dithiolan-3-yl)pentanoic acid. It contains a disulfide group, which can be transformed in the body to a dithiol group.

ALA has been on the market since the 1950s as a dietary supplement. It is a natural antioxidant usually made by the body. The advantage of ALA over other antioxidants such as vitamin C and E is that it is soluble both in water and in fat. Researchers in the former Soviet Union found that ALA can chelate mercury once it is transformed into the dithiol-containing compound. ALA can penetrate both the blood–brain barrier and the cell membrane and therefore would be a very interesting chelating agent. Nevertheless, there is much debate about its mode of action, side effects and effectiveness. Other antidotes, such as BAL and DMSA, are more efficient in the removal of heavy metals. ALA has not received FDA approval as a chelating agent, but it is still sold as a food supplement.

Purification Methods It forms yellow needles from cyclohexane or hexane and has been distilled at high vacuum; and sublimes at ~90o and very high vacuum. It is insoluble in H2O but dissolves in alkaline solution. [Lewis & Raphael J Chem Soc 4263 1962, Soper et al. J Am Chem Soc 76 4109, Reed & Niu J Am Chem Soc 77 416 1955, Tsuji et al. J Org Chem 43 3606 1978, Calvin Fed Proc USA 13 703 1954.] The S-benzylisothiuronium salt has m 153-154o (evacuated capillary, from MeOH), 132-134o, 135-137o (from EtOH). The dand lforms have m 45-47.5o and [] D 23 ±113o (c 1.88, *C6H6) and have UV in MeOH with max at 330nm ( 140). [Beilstein 19/7 V 237.] The reduced form, (±)-6,8-dimercaptooctanoic acid, [7516-48-5] M 208.3, is a light yellow liquid which is sold in sealed ampoules.

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

 

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

 

Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.

 

At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.

 

Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.