China (Mainland)
Silymarin /high standard CAS NO.65666-07-1
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- Min.Order: 1 Kilogram
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- Available Specifications:
99(0-25)Kilogram99(1-1000)Kilogram
- Product Details
Keywords
- Silymarin
- 65666-07-1
- USD$1/KG,IN STOCK
Quick Details
- ProName: Silymarin /high standard
- CasNo: 65666-07-1
- Molecular Formula: C25H22O10
- Appearance: powder
- Application: chemical
- DeliveryTime: Within 3 days after payment
- PackAge: foil aluminium bag/vacuum packing
- Port: Shanghai
- ProductionCapacity: 100 Kilogram/Day
- Purity: 85.0-99.8%
- Storage: keep in dry and cool condition
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
Product Name: Silymarin
Synonyms: SILYCHRISTIN(P);SILYMARINEXTRACT;Silymarin;2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Ccris 7096;Legalon;Legalon 70;Milk thistle (silybum marianum) extract or powder
CAS: 65666-07-1
MF: C25H22O10
MW: 482.44
EINECS: 613-830-9
Product Categories: Inhibitors;-
Mol File: 65666-07-1.mol
Silymarin Structure
Silymarin Chemical Properties
storage temp. −20°C
CAS DataBase Reference 65666-07-1(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
Provider Language
SigmaAldrich English
Silymarin Usage And Synthesis
Description Silymarin is a kind of flavonoid complex consisting of silybin, silydianin, and silychrisin, derived from the milk thistle plant. It is a kind of potent antioxidant, anti-cancer agent as well as liver protecting agent. It has a lot of pharmaceutical functions. For example: (1) Promotes healthy liver function and general health; (2) Strengthen the normal cellular defense system to protect the liver tissue; (3) Help to eliminate the toxin accumulating in the liver; (4) Increase the survival rate of patients of cirrhosis; (5) Protect our body against industrial poisons; (6) Antidote against the death cap mushroom. Silymarin exerts its pharmaceutical effects through various mechanism including scavenging free radicals, increasing glutathione (has detoxifying effect) level in the liver, increasing the levels of antioxidant enzymes such as superoxide dismutase, stimulating liver protein synthesis and inhibiting the synthesis of leukotrienes.
References #
http://172.16.24.181/www.mediherb.com/media/797348/silymarin-pds.pdf
Indications Milk thistle (Silybum [Carduus] marianus) is a spiny European plant with white-veined leaves and milky sap, the seed of which is used to treat liver disease.Milk thistle seed extract is used orally in the treatment of alcoholic and other cirrhoses and in Europe intravenously for its hepatoprotective effect in Amanita and other mushroom poisonings. It is grown in this country primarily as a “liver cleanser” and is reputed to protect this organ from a wide array of toxins.Milk thistle seed contains the active principle silymarin, a complex of flavonolignan compounds including silibinin (silybin), silidianin, and silychristin.
Mechanism of action Silymarin is thought to protect the liver by preventing the entry of toxins into the hepatocyte and by stimulating nucleolar polymerase A, which, in turn, increases protein synthesis and liver regeneration. Silymarin undergoes enterohepatic circulation, increasing its concentration in hepatocytes. It is also an antioxidant in its own right and is considered to have some cytoprotective effect against carcinogens.
Clinical Use Alcoholic cirrhosis has been improved (faster return of liver enzymes to baseline) in at least three trials, although one multicenter Spanish study failed to demonstrate any change in the clinical course.There is no evidence to support the use of milk thistle to increase alcohol tolerance, although it is certainly being used for this purpose. The effectiveness of silymarin for viral hepatitis is not clear, although several trials demonstrated enough benefit to encourage further studies.
Intravenous silymarin has been demonstrated to lower mortality from Amanita mushroom poisonings, but this formulation is available only in Europe.Animal studies have demonstrated hepatic protection against alcohol, acetaminophen, and mushroom toxins and protection against hepatic fibrosis with bile duct occlusion. There is also evidence of silybin protecting against cisplatin- induced nephrotoxicity in rats. It is not yet clear whether milk thistle extract offers any renal protection to humans.
Side effects Milk thistle appears to be remarkably safe, with loose stools due to increased bile solubility and occasional allergic reactions being the common side effects. It has not been evaluated in children or in pregnant women.There are no known serious drug or herb interactions.
Details
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