Product Name: Resveratrol
Synonyms: 5-[2-(4-hydroxyphenyl)vinyl]-1,3-benzenediol;Resveratrol - CAS 501-36-0 - Calbiochem;3,',5-Trihydroxystlbene;polygonum cuspidatum extract (resveratrol);Resveratrol 501-36-0;TRANS-3,4,5-TRIHYDROXYSTILBENE;TRANS-3,5,4'-STILBENETRIOL;TRANS-RESVERATROL
CAS: 501-36-0
MF: C14H12O3
MW: 228.24
EINECS: 610-504-8
Product Categories: plant extract-;Health supplements;Plant extracts;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;RESVEPURE;Stilbenes (substituted);Miscellaneous;Antioxidant;Biochemistry;-;Stilbenes;Natural Plant Extract;Beauty;The group of Polydatin;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Caspases/Apoptosis;natural product;Pyridines
Mol File: 501-36-0.mol
Resveratrol Structure
Resveratrol Chemical Properties
Melting point 253-255°C
storage temp. −20°C
form Powder
color Off-white
Water Solubility Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).
Merck 14,8158
InChIKey LUKBXSAWLPMMSZ-OWOJBTEDSA-N
CAS DataBase Reference 501-36-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41-36/38-36-43-22
Safety Statements 26-39-37/39-36/37/39
WGK Germany 3
RTECS CZ8987000
HS Code 29072990
Hazardous Substances Data 501-36-0(Hazardous Substances Data)
MSDS Information
Provider Language
5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol English
SigmaAldrich English
Resveratrol Usage And Synthesis
description
Resveratrol is a natural antioxidant. It can reduce blood viscosity, inhibit platelet aggregation and vasodilation, keep the blood flowing and prevent the occurrence and development of cancer. It has the function to prevent and treat atherosclerosis, coronary heart disease, ischemic heart disease and high blood cholesterol. It has an effect on suppressing tumor. Resveratrol also has estrogen-like effects that can be used to treat breast cancer and other diseases. It can retard aging and prevent cancer. Red grape skins, red wine and grape juice have high concentrations of resveratrol. Studies have shown that the integrity of the chromosomes will be destroyed as the human aging. But resveratrol can activate proteins that can repair chromosome, thus delaying aging.
Resveratrol is a polyphenolic phytoalexin. It is also classified as a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. The levels of resveratrol found in food varies greatly. Red wine contains between 0. 2 and 5. 8 mg/L depending on the grape variety, while white wine has much less. The reason for this difference is that red wine is fermented with grape skins, allowing the wine to absorb the resveratrol, whereas white wine is fermented after the skin has been removed.
Resveratrol is a very effective anti-oxidant with 95% efficiency in preventing lipid peroxidation as compared with 37% for Vitamin C or 65% for Vitamin E. It has very strong peroxyl radical scavenging abilities, more than gallic and ellagic acids and epicatechins. Resveratrol has been shown to protect against UVB mediated skin damage in mice by boosting anti-oxidant defenses, and it has been shown to help alleviate skin wounds.
Resveratrol is effective against photoaging due, in part, to its anti-oxidant properties, and is recommended for use in pre- or post-sun exposure products. Resveratrol can pass through the stratum corneum to be found in the dermis and epidermis. It has been shown to preserve dermal collagen, and may be effective in enhancing glycosaminoglycans, which enhance tissue hydration. It has been shown to stimulate skin’s cellular renewal, and help increase skin's thickness. And it has been shown to inhibit tyrosinase, which indicates its use for reducing hyperpigmentation.
Resveratrol Benefits and ralting biological activities Much of the research pointing to the benefits have been laboratory or animal-based studies. So far, research on resveratrol's effectiveness in humans has yielded mixed results.