Curcumin 458-37-7 CAS NO.458-37-7

Product Name:	Curcumin
Synonyms:	Curcumin, Natural Yellow 3, Diferuloylmethane;Curcumin 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;Curcumin solution ;Curcumin, Curcuma longa (High Purity);Curcuimn;CURCUMIN FROM CURCUMA LONGA CRYSTALL;Curcumin (mixture of curcumin;TURMERIC EXTRACT
CAS:	458-37-7
MF:	C21H20O6
MW:	368.38
EINECS:	207-280-5
Product Categories:	phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Diferuloylmethane, Natural Yellow 3, C.I. 75300;pigment;Miscellaneous Natural Products;Analytical Chemistry;Antioxidant;Biochemistry;Indicator (pH);pH Indicators;Colorants;Natural Plant Extract;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;Chalcone;Miscellaneous
Mol File:	458-37-7.mol

Curcumin Chemical Properties

Melting point	183 °C
density	0.93
vapor density	13 (vs air)
refractive index	1.4155-1.4175
Fp	14℃
storage temp.	−20°C
solubility	ethanol: 10 mg/mL
form	powder
Colour Index	75300
pka	8.09(at 25℃)
color	orange
PH Range	Yellow (7.8) to red-brown (9.2)
Water Solubility	Slightly soluble (hot)
λmax	430nm
Merck	14,2673
BRN	2306965
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major Application	Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
CAS DataBase Reference	458-37-7(CAS DataBase Reference)
EPA Substance Registry System	1,6-Heptadiene-3, 5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-(458-37-7)

Safety Information

Hazard Codes	Xi,F
Risk Statements	36/37/38-11
Safety Statements	26-36-16-7-37/39
RIDADR	UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany	2
RTECS	MI5230000
Hazard Note	Irritant
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29145000
Hazardous Substances Data	458-37-7(Hazardous Substances Data)

Curcumin Usage And Synthesis

Chemical Properties	orange crystalline powder
Uses	A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Uses	antiedemic, antiinflammatory, bile stimulant; antibacterial, antifungal, lipo/cyclooxygenase inhibitor
Uses	Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two t
Definition	ChEBI: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Uses	For preparing curcuma paper, pH range 8-9. In the detection of boron.
General Description	Orange-yellow needles.
Air & Water Reactions	Slightly soluble in hot water .
Reactivity Profile	Curcumin is sensitive to light and changes in pH. Curcumin may react with oxidizing materials.
Biological Activity	Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNF α , IL-1, IL-6, PKC, EGFR, NF- κ B, I κ B kinase and more. Upregulates expression of PPAR γ , p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo .

 

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

 

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

 

Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.

 

At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.

 

Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.