China (Mainland)
Monoethyl fumarate competitive product CAS NO.2459-05-4
- FOB Price: USD: 0.10-0.10 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: T/T,Other
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High quality(1-25)Kilogram
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Quick Details
- ProName: Monoethyl fumarate competitive produc...
- CasNo: 2459-05-4
- Molecular Formula: C6H8O4
- Appearance: according to email quotation
- Application: pharmaceutical raw materials
- DeliveryTime: Within 3 days after payment
- PackAge: foil aluminium bag/vacuum packing
- Port: Shanghai
- ProductionCapacity: 100 Kilogram/Week
- Purity: 99%
- Storage: Keep in dry and cool condition
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- CAS No.: 2459-05-4
- Synonyms: (2E)-4-Ethoxy-4-oxo-2-butenoic acid
- Formula: C6H8O4
- Molecular Weight: 144.13
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Coreychem competetive product
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Coreychem focus on high complex new type intermediates and fine chemical custom synthesis,scale-up production and rare chemicals trade.Product category including Intermediates&API,Catalyst and Electronic Chemicals.Covering 811 square meters R&D center,with 45 person R&D team,our synthesis level is well-known to the industry,which are exported to France,Poland,Czech,Ukraine,Spain,Switzerland,etc...
Details
| Product Name: | Monoethyl fumarate |
| Synonyms: | (2E)-4-Ethoxy-4-oxo-2-butenoic acid;2-Butenedioic acid (E)-, monoethyl ester;(2E)-2-Butenedioic Acid Monoethyl Ester;FuMaric Acid Ethyl Ester;Monoethyl FuMerate;Monoethyl trans-2-Butenedioate;Ethyl Hydrogen Fumarate Fumaric Acid Monoethyl Ester;Monoethyl FuMarate (Quetiapine IMpurity R) |
| CAS: | 2459-05-4 |
| MF: | C6H8O4 |
| MW: | 144.13 |
| EINECS: | 219-544-7 |
| Product Categories: | Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;mildew preventive |
| Mol File: | 2459-05-4.mol |
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| Monoethyl fumarate Chemical Properties |
| Melting point | 66-68 °C(lit.) |
| Boiling point | 147 °C16 mm Hg(lit.) |
| density | 1.1109 |
| refractive index | 1.4500 (estimate) |
| storage temp. | Refrigerator |
| form | Crystalline Powder |
| color | Almost white to beige |
| Water Solubility | Soluble in water. |
| BRN | 1723588 |
| CAS DataBase Reference | 2459-05-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethyl hydrogen fumarate(2459-05-4) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 1 |
| HazardClass | IRRITANT |
| HS Code | 29171900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Monoethyl fumarate Usage And Synthesis |
| Description | Monoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed blood–brain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment. |
| References |
Thio, H. B., et al. "Long‐term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm®;) in psoriasis." Journal of the European Academy of Dermatology & Venereology 4.1(1995):35-40. Asadullah, K, et al. "Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis ." Archives of Dermatological Research 289.11(1997):623-30. Lim, J. L., et al. "Protective effects of monomethyl fumarate at the inflamed blood-brain barrier." Microvascular Research 105(2016):61. Zhao, Wen Xiu, C. M. Zhang, and X. U. Xue-Ming. "Synthesis and antimicrobial active of monomethyl fumarate." Science & Technology of Food Industry (2008). Helwa, Inas. "The Mechanism of Monomethylfumarate (MMF) as an Anti-psoriatic Agent." Helwa Inas (2014) |
| Chemical Properties | ALMOST WHITE TO BEIGE CRYSTALLINE POWDER |