China (Mainland)
(2-hydroxypropyl)--cyclodextrin CAS NO.128446-35-5
- FOB Price: USD: 1.00-1.00 /Metric Ton Get Latest Price
- Min.Order: 2 Kilogram
- Payment Terms: T/T,Other
- Available Specifications:
98(0-25)Metric Ton98(1-100)Metric Ton
- Product Details
Keywords
- (2-hydroxypropyl)--cyclodextrin
- 128446-35-5
- High Cost-Effective
Quick Details
- ProName: (2-hydroxypropyl)--cyclodextrin
- CasNo: 128446-35-5
- Molecular Formula: C63H112O42
- Appearance: powder
- Application: intermediates
- DeliveryTime: Within 3 days after payment
- PackAge: foil aluminium bag/vacuum packing
- Port: shanghai
- ProductionCapacity: 150 Kilogram/Week
- Purity: 98%
- Storage: Keep in dry and cool condition
- Transportation: by air or by sea
- LimitNum: 2 Kilogram
- Melting Point: 278oC (dec.)
- Storage Temp: 2-8oC
- Appearance: white to slightly yellow powder
- RTECS: GU2293332
- Safety Statements: S24/25
- WGK Germany: 3
- CAS No.: 128446-35-5
- Synonyms: (2-HYDROXYPROPYL)--CYCLODEXTRIN;
- Formula: C63H112O42
- Exact Mass: 1540.66000
Superiority
Product Name: 2-Hydroxypropyl-β-cyclodextrin
Synonyms: Hydroxypropyl beta cyclodextrin aqueous solution;Injection grade hydroxypropyl betadex;Pharmaceutical grade hydroxypropyl betadex;Technical grade hydroxypropyl beta cyclodextrin;beta-hydroxypropylcyclodextrin;(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;(2-Hydroxypropyl)-β-cyclodextrin;2-Hydroxypropyl-B-Cyclodextrin
CAS: 128446-35-5
MF: C63H112O42
MW: 1541.54
EINECS: 420-920-1
Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;-;Chelation/Complexation Compounds;Synthetic Reagents;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools;Carbohydrates & Derivatives;Other APIs
Mol File: 128446-35-5.mol
2-Hydroxypropyl-β-cyclodextrin Structure
2-Hydroxypropyl-β-cyclodextrin Chemical Properties
Melting point 278 °C (dec.)
refractive index 125 ° (C=1, H2O)
storage temp. 2-8°C
solubility H2O: 45 % (w/v)
form solution (clear, colorless)
color White to slightly yellow
optical activity [α]26/D +139°, c = 1 in H2O
Water Solubility Soluble in water.
InChIKey ODLHGICHYURWBS-FOSILIAISA-N
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS GU2293332
TSCA Yes
HS Code 29400090
MSDS Information
Provider Language
SigmaAldrich English
2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis
Chemical Properties White to slightly yellow powder
Chemical Properties Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
Uses 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
Uses enteric coating, sustained release formulations, buccal and transdermal drug delivery
Uses 2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
Production Methods Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.
Pharmaceutical Applications Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.
Safety The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.
storage Store in well-closed containers.
Regulatory Status Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.
Details
Molecular Weight:1541.54000
PSA:618.66000
LogP:-12.39490
| (2-hydroxypropyl)--cyclodextrin | |
| CAS No.: | 128446-35-5 |
|---|---|
| Synonyms: | |
| Formula: | C63H112O42 |
| Exact Mass: | 1540.66000 |
| Molecular Weight: | 1541.54000 |
| PSA: | 618.66000 |
| LogP: | -12.39490 |
|
Properties
|
|
| Melting Point: | 278oC (dec.) |
|---|---|
| Storage Temp: | 2-8oC |
| Appearance: | white to slightly yellow powder |
|
Safety Info
|
|
| RTECS: | GU2293332 |
|---|---|
| Safety Statements: | S24/25 |
| WGK Germany: | 3 |
Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates fine chemicals custom synthesis, scale-up production and rare chemicals trade. We have experienced research staff, strong technical force, well-equipped machine, and considerate marketing team service, with a strict customer intellectual property security system, we are already become good partner of customers from difficult and complex chemical and biological chemical field. Our high quality & low price and effective services shortened new product development cycle,reduced the development and production cost for numerous partners.
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