Silica gel(white/orange/blue) CAS NO.112926-00-8

Product Name:	Silica gel
Synonyms:	PEI-Silica gel ;THE(R) DESICCANT;SILICON DIOXIDE PYROGENE, HIGHDISPERS;SILICON(IV) OXIDE;SILVER NITRATE-IMPREGNATED SILICA GEL;SULFURIC ACID-IMPREGNATED SILICA GEL;SAND;SILICA GEL
CAS:	112926-00-8
MF:	O2Si
MW:	60.0800018310547
EINECS:	601-214-2
Product Categories:	Silica Gels;Adsorbents (Inorganic);LPLC Separation Media;Silica;Davisil SilicaEssential Chemicals; Chemical Properties white to off-white powder Chemical Properties Amorphous silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder Uses Silica gel was used on glass plates for preparative TLC and on aluminium sheets for analytical TLC. Silica gel was used in vacuum chromatography and TLC. Silica gel was used in column chromatography. Definition A gel made by coagulating sodium silicate sol. The gel is dried by heatheating and used as a catalyst support and as a drying agent. The silica gel used in desiccators and in packaging to remove moisture is often colored with a cobalt salt to indicate whether it is still active (blue=dry; pink=moist). Definition A rigid gel made by coagulatinga sol of sodium silicate andheating to drive off water. It is usedas a support for catalysts and also asa drying agent because it readily absorbsmoisture from the air. The gelitself is colourless but, when used indesiccators, etc., a blue cobalt salt isadded. As moisture is taken up, thesalt turns pink, indicating that thegel needs to be regenerated (by heating). Agricultural Uses A hard granular hygroscopic form of hydrated silica is called silica gel. It is made by heating a coagulated sol of sodium silicate. It is used as a catalyst and a desiccant. Potential Exposure Amorphous fumed silica is used as a mineral, natural or synthetic fiber. A potential danger to those involved in the production and handling of fumed silica for paint pigments or catalysts. Diatomaceous earth is used in clarifying liquids, in manufacture of fire brick and heat insulators; used as a filtering agent; as a filler in construction materials; pesticides, paints, and varnishes. A potential danger to those involved in mining of diatomaceous earth or fabrication of products there from. Purification Methods Before use as a drying agent, silica gel is heated in an oven, then cooled in a desiccator. Conditions in the literature range from heating at 110o for 15hours to 250o for 2-3hours. Silica gel has been purified by washing with hot acid (in one case successively with aqua regia, conc HNO3, then conc HCl; in another case it was digested overnight with hot conc H2SO4), followed by exhaustive washing with distilled water (one week in a Soxhlet apparatus has also been used), and prolonged oven drying. Alternatively, silica gel has been extracted with acetone until all soluble material was removed, then dried in a current of air, washed with distilled water and oven dried. Silica gel has also been washed successively with water, M HCl, water, and acetone, then activated at 110o for 15hours. Silicon monoxide [10097 -28 -6] M 44.1, m > 1700o, d 4 2.18. Purify the monoxide by sublimation in a porcelain tube in a furnace at 1250o (4hours) in a high vacuum (10-4mm) in a stream of N2. It is obtained as brownish black scales. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 696 1963.] Incompatibilities Silica, amorphous is a noncombustible solid. Generally unreactive chemically. Incompatible with fluorine, oxygen difluoride, chlorine trifluoride. Soluble in molten alkalis and reacts with most metallic oxides at high temperature. Waste Disposal Sanitary landfill.   Silica gel Preparation Products And Raw materials Preparation Products (2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL)METHANAMINE-->3-Nitroisonicotinic acid-->Dodecanamine-->SEMOTIADIL-->2-(TRIFLUOROMETHYL)PYRIMIDIN-5-AMINE-->4-ISOCYANOBENZOPHENONE-->(2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL)METHANOL-->2'-BENZYLOXYACETOPHENONE-->2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXAMIDE-->2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONYL CHLORIDE-->4-DIMETHYLAMINOBUTYLAMINE-->4-(DIETHYLAMINO)BUTYLAMINE-->3-Methyl-4-(methylthio)phenol-->Lamivudine-->[2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate-->Carbon tetrafluoride -->BUCILLAMINE-->2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID-->ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE-->4-Amino-2-chloropyrimidine-->2-Methylbutane-->VINYL FLUORIDE-->Pyribenzoxim-->Tacalcitol-->1-(2-Methoxyphenyl)piperazine-->2-(Methylamino)pyridine-->Cladribine-->Montelukast-->Decylamine-->Cidofovir-->Sertaconazole nitrate-->Lanoconazole-->Ubidecarenone-->Bis(pyridine)iodonium tetrafluoroborate-->Pirarubicin-->Paclitaxel-->Naphthalene oxidation catalyst-->nitrobenzene hydrogenation catalyst for making aniline-->FNG silica gel-->silver nickel catalyst Raw materials Cobalt chloride-->Silica gel,microporous roundness-->Poly(ethylene glycol) dimethacrylate-->silica gel fine-pored lump-->SILICA Resins&LC Separation Media;Silica TLC Adsorbent, with fluorescent indicator, no binder;Silica Gels;UVCBs-inorganic;Fluka brand Silica, TLC Adsorbent;Other Silica Gels;Fluka brand Silica, TLC AdsorbentBulk Adsorbents for TLC;Silica TLC Adsorbent, with binder, no indicator;Bulk Adsorbents for TLC;-;Silica TLC Adsorbent, no binder, no fluorescent indicator;Silica TLC Adsorbents;SilicaBulk Adsorbents for TLC;Davisil GradesResins&LC Separation Media;Davisil Silica;Essential Chemicals;metals scavenging agent;supported alkali metal;Desiccators and Desiccants;Desiccants;Labware
Mol File:	Mol File

Silica gel Chemical Properties

Melting point	1610°C
Boiling point	2230℃
density	2.6
Fp	23°C
storage temp.	2-8°C
form	powder or granules
Specific Gravity	0.88g/ml
color	blue
PH	~6.8 (10% in aq. suspension)
Merck	14,8493
CAS DataBase Reference	112926-00-8
EPA Substance Registry System	Silica gel, pptd., cryst.-free(112926-00-8)

Safety Information

Hazard Codes	Xi,T,N,Xn
Risk Statements	20-37-42/43-49-36/37-48/20-51/53-68-50/53-41-22-60
Safety Statements	22-24/25-45-36/37-53-26-36-61-60-39
RIDADR	1993
WGK Germany	2
RTECS	VV7315000
F	3
Hazard Note	Harmful/Irritant
TSCA	Yes

 

 

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

 

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

 

Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.

 

At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.

 

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