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Home > Products >  Corey Nepafenac

Corey Nepafenac CAS NO.78281-72-8

  • FOB Price: USD 1 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T
  • Available Specifications:

    99(1-5)Kilogram

  • Product Details

Keywords

  • Nepafenac
  • 78281-72-8
  • 2-Amino-3-benzoylbenzeneacetamide;nepafenac,Nevance

Quick Details

  • ProName: Corey Nepafenac
  • CasNo: 78281-72-8
  • Molecular Formula: C15H14N2O2
  • Appearance: solid
  • Application: pharm intermediate
  • DeliveryTime: as order details
  • PackAge: standard export packing
  • Port: China main port
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99%
  • Storage: standard stock condition
  • Transportation: by air
  • LimitNum: 1 Kilogram
  • Moisture Content: stamd requirement
  • Impurity: stamd requirement
  • Brand: Corey

Superiority

Henan CoreyChem Co., Ltd, established in 2014 and based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis; 

 

Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff.

 

The company has completed numerous domestic and overseas famous pharmaceutical, chemical, biological and other large and medium-sized company R&D outsourcing services, synthesis process development and optimization services, chemical intermediates customized service, special chemical processing and production services, etc., We hope to become continuous mutually beneficial partnership with you, to create a better business opportunities together.

 

Business Scope:

Technical research and technology transfer of pharmaceutical intermediates, biological preparations, small-scale screening of organic synthesis of fine chemicals, pilot scale amplification and mass production schemes; sales: nano-new materials, metal catalysts, cosmetic raw materials, pharmaceutical intermediates, chemicals Products (except flammable, explosive, dangerous goods), photoelectric materials

Details

Nepafenac Basic information
Ophthalmic drugs (cataract)
Product Name: Nepafenac
Synonyms: AHR 9434;AL 6515;Nevanac;Nepafenac - WS;Nepafenac;2-(2-amino-3-benzoyl-phenyl)acetamide;2-Amino-3-benzoylbenzeneacetamide;nepafenac,Nevance
CAS: 78281-72-8
MF: C15H14N2O2
MW: 254.28
EINECS:  
Product Categories: Pharmaceuticals;Pharmaceutical intermediate;Nevanac;Other APIs;Amines;Aromatics;-;Intermediates & Fine Chemicals;Isotope Labelled Compounds
Mol File: 78281-72-8.mol
Nepafenac Structure
 
Nepafenac Chemical Properties
Melting point  177-181°C
storage temp.  Refrigerator
solubility  DMSO: ≥5mg/mL
form  powder
color  faint yellow to dark yellow
Merck  14,6469
InChIKey QEFAQIPZVLVERP-UHFFFAOYSA-N
CAS DataBase Reference 78281-72-8(CAS DataBase Reference)
 
Safety Information
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  CY1480710
MSDS Information
 
 
Nepafenac Usage And Synthesis
Ophthalmic drugs (cataract) Nepafenac is a novel ophthalmic non-steroidal anti-inflammatory drug (NSAID), for the treatment of eye pain and inflammation caused by cataract surgery, compared with traditional NSAIDs, chemical structure of Nepafenac is conducive to make it rapidly penetrate the cornea and distribute to its target site, which is helpful to reduce the accumulation of the drug in the corneal surface and to reduce the incidence of complications of the eye surface, it has many advantages such as infiltration, targeting strong, little toxic side effects and so on. 
August 19, 2005 ,the US Food and Drug Administration (FDA) approved nepafenac ophthalmic suspension for the treatment of cataract surgery-related pain and inflammation, it is the first ophthalmic NSAID prodrug formulation approved for marketing. 
Nepafenac after ocular administration, can rapidly pass through the cornea , and under the action of eye tissue hydrolytic enzymes,it can become into ammonia diclofenac (a kind of NSAID); and ammonia diclofenac by inhibiting prostaglandin H synthase ( cyclooxygenase), can block prostaglandin synthesis to play its role as an anti-inflammatory analgesic. As is known, prostaglandin is one of the media causing ocular inflammation it can lead to blood-aqueous barrier crash, vasodilatation, increased vascular permeability and leukocyte chemotaxis, etc. In addition, prostaglandins can also control contraction of the iris sphincter through non-cholinergic mechanism which can trigger the miosis reaction during eye surgery and after surgery. After ocular administration of NSAIDs, it can inhibit prostaglandins synthesis in the iris, ciliary body and conjunctiva, so people can prevent eye inflammation, and reduce the associated pain.
The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties Light Yellow Solid
Uses Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop. It reduces pain and inflammation in the eyes. Nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery. Its side effects may inclu
Uses Labelled Nepafenac (N390080). A non-steroidal anti-inflammatory with analgesic activity; selective COX-2 inhibitor. Prodrug of Amfenac.
Definition ChEBI: A monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted to the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery.
Brand name Nevanac (Alcon).

 

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