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Home > Products >  High quality of Prilocaine

High quality of Prilocaine CAS NO.721-50-6

  • Product Details

Keywords

  • MF: C13H20N2O
  • MW: 220.31
  • EINECS: 211-957-0

Quick Details

  • ProName: High quality of Prilocaine
  • CasNo: 721-50-6
  • Molecular Formula: C13H20N2O
  • Appearance: White or off-white crystalline powder
  • Application: astra1515;Citanest;L 67;l67;n-(2-methy...
  • DeliveryTime: When the clients finished the payment
  • PackAge: According to the nature of the product
  • Port: Shanghai
  • ProductionCapacity: 1000 Kilogram/Month
  • Purity: 99%
  • Storage: Low temperature, dry, protected from l...
  • Transportation: According to the clients requirement.
  • LimitNum: 1 Metric Ton
  • Moisture Content: standard
  • Impurity: standard

Superiority

JD205

Product Name: Prilocaine
Synonyms: astra1515;Citanest;L 67;l67;n-(2-methylphenyl)-2-(propylamino)-propanamid;o-Methyl-2-propylaminopropionanilide;o-Methyl-alpha-propylaminopropionanilide;o-Propionotoluidide, 2-(propylamino)-
CAS: 721-50-6
MF: C13H20N2O
MW: 220.31
EINECS: 211-957-0
Product Categories: Pharmaceutical Intermediates-;Active Pharmaceutical Ingredients;Inhibitors;research chemical
Mol File: 721-50-6.mol
Prilocaine Structure
 
Prilocaine Chemical Properties
Melting point  37-38°
Boiling point  bp0.1 159-162°
density  1.0117 (rough estimate)
refractive index  nD20 1.5298
solubility  Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).
form  neat
pka pKa 7.32 or 7.89 (Uncertain)
CAS DataBase Reference 721-50-6(CAS DataBase Reference)
NIST Chemistry Reference Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)
 
Safety Information
Hazardous Substances Data 721-50-6(Hazardous Substances Data)
MSDS Information
 
 
Prilocaine Usage And Synthesis
Local anesthetic drug Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline. 
[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6~7min and the duration time of about 1.5~2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta. 
[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring. 
[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia. 
[Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.
the structural formula of prilocaine
Figure 1 the structural formula of prilocaine
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties It is a kind of needle-like crystals with the melting point being 37-38 ℃ and the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless.
Uses It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.
Production method O-toluidine and α-bromo-propionyl bromide are condensed and further have reaction with propylamine obtain prilocaine.
Chemical Properties White or almost white, crystalline powder.
Uses Local anaesthetic.
Definition ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

 

Details

Career Henan Chemical Co, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates fine chemicals custom synthesis, scale-up production and rare chemicals trade. We have experienced research staff, strong technical force, well-equipped machine, and considerate marketing team service, with a strict customer intellectual property security system, we are already become good partner of customers from difficult and complex chemical and biological chemical field. Our high quality & low price and effective services shortened new product development cycle,reduced the development and production cost for numerous partners.

 

The company has completed numerous domestic and overseas famous pharmaceutical, chemical, biological and other large and medium-sized company R&D outsourcing services, synthesis process development and optimization services, chemical intermediates customized service, special chemical processing and production services, etc., We hope to become continuous mutually beneficial partnership with you, to create a better business opportunities together.

 

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1. Samples synthetic, Our strong r&d team has accumulated abundant experience in synthesis design and exploring synthesis of new technology. Not only good at heterocyclic chemistry, chiral chemicals (asymmetric synthesis and enzyme reaction), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry including nucleosides, nucleotides, sugar chemical, peptide chemistry, etc, to complete the synthesis from mg to kg samples in lab scale. Our efficient management and good communication skills and ability to solve the problem rapidly in order to ensure quality, timely delivery, based on the standard client confidential system and competitive price products,we has been recognized and praised by many customers in chemical industry.
       

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3.Technology transfer, the company has accumulated a large number of production processes of drugs, intermediates and raw material. Based on the principle of mutual benefit, and some technology transfer to industry manufacturers, also provides them marketing support.
  

4. Purchasing agency service, Our excellence professional sales team, timely and thoughtful service, in addition to the necessary good language communication ability of professional sales staff, also equipped with professional chemical technical sales consultant, who can answer the customer's academic professional question, we are in line with the aim of offering customer wholehearted service, with our advanced testing equipment checks and abundant R&D and production of domestic partner contacts, to provide rare chemicals with standard purity, reasonable price and cost-effective purchasing agency service to foreign customers, and the help you shorten the sourcing time, reduce the purchasing cost.

 

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