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Home > Products >  Corey Miltefosine

Corey Miltefosine CAS NO.58066-85-6

  • msdsMSDS/COA Download

  • FOB Price: USD 1 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,Western Union
  • Available Specifications:

    98(1-10)Kilogram

  • Product Details

Keywords

  • mil;C16:0;C16 : O;CHOLINE HEXADECYL PHOSPHATE;HPC;HEPC;HEXADECYL PHOSPHORYLCHOLINE;HEXADECYLPHOSPHOCHOLINE
  • 58066-85-6
  • mil;C16:0;C16 : O;CHOLINE HEXADECYL PHOSPHATE;HPC;HEPC;HEXADECYL PHOSPHORYLCHOLINE;HEXADECYLPHOSPHOCHOLINE

Quick Details

  • ProName: Corey Miltefosine
  • CasNo: 58066-85-6
  • Molecular Formula: C21H46NO4P
  • Appearance: white powder
  • Application: acts as an Akt inhibitor, and under in...
  • DeliveryTime: as order details
  • PackAge: standard export packing
  • Port: China main port
  • ProductionCapacity: 10 Kilogram/Month
  • Purity: 98% HPLC
  • Storage: standard stock condition
  • Transportation: by air, by express, by exprss
  • LimitNum: 1 Kilogram
  • Moisture Content: stamd requirement
  • Impurity: stamd requirement
  • MW: 407.57
  • Brand: corey

Superiority

Miltefosine Basic information
Product Name: Miltefosine
Synonyms: mil;C16:0;C16 : O;CHOLINE HEXADECYL PHOSPHATE;HPC;HEPC;HEXADECYL PHOSPHORYLCHOLINE;HEXADECYLPHOSPHOCHOLINE
CAS: 58066-85-6
MF: C21H46NO4P
MW: 407.57
EINECS: 622-572-6
Product Categories: Miscellaneous Natural Products;-;Anti-virals;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;MILTEX;inhibitor;Anti-cancer&immunity;Inhibitors
Mol File: 58066-85-6.mol
Miltefosine Structure
 
Miltefosine Chemical Properties
Melting point  232-234° (dec)
storage temp.  room temp
solubility  H2O: soluble10mg/mL, clear, colorless
form  Crystalline solid
CAS DataBase Reference 58066-85-6(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-43
Safety Statements  36/37
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  KH2890000
Toxicity LD50 in rats (mg/kg): 246 orally (Muschiol)
MSDS Information
 
 
Miltefosine Usage And Synthesis
Uses A phospholipid drug with antineoplastic and antiprotozoal/antifungal properties, also acts as an Akt inhibitor, and under investigation as a potential therapy against HIV infection.
Definition ChEBI: A phospholipid that is the hexadecyl monoester of phosphocholine.
Antimicrobial activity Concentrations of 1–5 μm inhibit the promastigotes and amastigotes of Leishmania spp. and the epimastigotes and amastigotes of T. cruzi. Inhibitory concentrations against T. brucei spp. and E. histolytica are closer to 50 μm. Acanthamoeba spp. are variably susceptible, depending on the experimental conditions.
Acquired resistance There are no reports of clinical resistance in Leishmania so far. Experimental resistance has been induced in vitro against the promastigote stage of Leishmania and two plasma membrane proteins, LdMT and Ld Ros3, are necessary for miltefosine uptake. There is evidence that reduced sensitivity of promastigotes is passed on to intracellular amastigotes.
Pharmaceutical Applications An alkylphospholipid, originally investigated as an anticancer compound, formulated for oral administration.
Pharmacokinetics In rodent models the drug is almost completely absorbed after oral administration. About 90% is bound to plasma proteins. It is widely distributed in the body; studies in rats showed highest uptake in kidney, liver and spleen. In rats and dogs bioavailability was 82% and 94%, with maximum values reached after 4–48 h.
In adult human trials repeated oral dosing with 100 mg per day achieved a peak plasma concentration of 70 mg/L after 8–24 h (day 23). The half-life is 6–8 days.
Clinical Use Visceral leishmaniasis
Cutaneous leishmaniasis
Side effects Mild to moderate gastrointestinal side effects are reported in 40–60% of patients. Moderate to severe nephrotoxicity was seen in 2% and 1% of patients, respectively; increases in creatinine levels were reversible. Miltefosine is contraindicated in pregnancy, based on findings of teratogenicity in rats. It causes hemolysis and cannot be given intravenously.

 

Details

Henan CoreyChem Co., Ltd, established in 2014 and based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis; 

 

Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff.

 

The company has completed numerous domestic and overseas famous pharmaceutical, chemical, biological and other large and medium-sized company R&D outsourcing services, synthesis process development and optimization services, chemical intermediates customized service, special chemical processing and production services, etc., We hope to become continuous mutually beneficial partnership with you, to create a better business opportunities together.

 

Business Scope:

Technical research and technology transfer of pharmaceutical intermediates, biological preparations, small-scale screening of organic synthesis of fine chemicals, pilot scale amplification and mass production schemes; sales: nano-new materials, metal catalysts, cosmetic raw materials, pharmaceutical intermediates, chemicals Products (except flammable, explosive, dangerous goods), photoelectric materials

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