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low price D(+)-Tryptophan with high quality CAS NO.153-94-6

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Keywords

  • D(+)-Tryptophan
  • D-TRP
  • D(+)-TRYPTOPHAN

Quick Details

  • ProName: low price D(+)-Tryptophan with high qu...
  • CasNo: 153-94-6
  • Molecular Formula: C11H12N2O2
  • Appearance: White Crystalline Powder
  • Application: Amino Acid Derivatives;Glutamic acid [...
  • DeliveryTime: ASAP / Prompt upon the Payment terms
  • PackAge: Customized
  • Port: Qingdao,Shanghai, Tianjin
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99%
  • Storage: Cool and dry place
  • Transportation: by sea, by air
  • LimitNum: 1 Kilogram
  • Moisture Content: 0.1
  • Residual Solvent: 0.01
  • Heavy Metal: 0.001
  • Assay: 99.95%
  • MW: 204.23
  • EINECS: 205-819-9
  • MF: C11H12N2O2

Superiority

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 
Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.
 
At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.
 
Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.

Details

D(+)-Tryptophan Basic information
Description Description Characteristics and Functions Project Standards Application References References
Product Name: D(+)-Tryptophan
Synonyms: D-TRP;D(+)-TRYPTOPHAN;D-TRYPTOPHAN;D-TRYPTOPHANE;D-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID;D-2-AMINO-3-INDOLEPROPIONIC ACID;D-2-AMINO-3-INDOLYLPROPANOIC ACID;D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID
CAS: 153-94-6
MF: C11H12N2O2
MW: 204.23
EINECS: 205-819-9
Product Categories: Amino Acids Derivatives;Amino Acid Derivatives;Tryptophan [Trp, W];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Indoles;Tryptophans;Chiral Compound;Amino Acids;Amino Acids & Derivatives;Aromatics;Heterocycles;Indole Derivatives;Isotope Labelled Compounds;Intermediate of Tadalafil;tadalafil intermediate;Thiophenes
Mol File: 153-94-6.mol
D(+)-Tryptophan Structure
 
D(+)-Tryptophan Chemical Properties
Melting point  282-285 °C (dec.)(lit.)
alpha  31.5 º (c=1, H2O 24 ºC)
refractive index  31 ° (C=1, H2O)
storage temp.  Store at RT.
form  Powder
color  White to slightly yellow
Water Solubility  11 g/L (20 ºC)
BRN  86198
Stability: Stable. Incompatible with oxidizing agents.
InChIKey QIVBCDIJIAJPQS-SECBINFHSA-N
CAS DataBase Reference 153-94-6(CAS DataBase Reference)
EPA Substance Registry System D-Tryptophan(153-94-6)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38-41-37/38-22
Safety Statements  24/25-36/37/39-36-26
WGK Germany  3
RTECS  YN6129000
8
TSCA  Yes
HazardClass  IRRITANT
HS Code  29339990
MSDS Information
Provider Language
(R)-2-Amino-3-(3-indolyl)propionic acid English
ACROS English
SigmaAldrich English
ALFA English
 
D(+)-Tryptophan Usage And Synthesis
Description D(+)-tryptophan is the D-form (non-proteinogenic form) of the amino acid tryptophan. It can be used for Human embryonic kidney cell (HEK-293, ATCC: CRL-1573) culture. It is also a sweetener used to study the release of incretins from enteroendocrine cells triggered by sugar but not by sweeteners.
Description D-tryptophan (Full name D (+)-Tryptophan) is a white to pale yellow or white crystalline powder at room temperature, odorless or slight odor, slightly sweet taste. Solubility in water is 1.14 g (25 ℃), soluble in dilute acid and alkali, stable in alkali, decomposed in strong acid, slightly soluble in ethanol, not soluble in chloroform, ethyl ether. It plays an important role for human and animal growth and development, metabolism, known as the second essential amino acids. They are almost identical with L-type and physical and chemical properties, and only the optical activity is opposite. But their distribution, function and coenzyme have diversity. Its melting point is very high, generally above 200 degrees. It can dissolve in water, and in the near UV region it has the ability to absorb light.
Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. the D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). The distinguishing structural characteristic of tryptophan is that it contains an indole functional group. It is an essential amino acid as defined by its growth effects on rats.
Characteristics and Functions D-tryptophan amino acid, as a non-reactive protein, has special physiological properties. It can be used as a non-nutritive sweeteners, feed additive, plant growth agents in food feed industry and agriculture. In the pharmaceutical industry, it mainly used for the synthesis of various polypeptides, instead of L-tryptophan peptide drug for half-life extending and reduce the side effects, but it will not resistant to the front body, and it will become important enzyme inhibitor. It can also improve the body's immunity, delayed allergic reactions. Most peptide antibiotic can resistant gram-positive bacteria, Gram-negative bacteria and some, such as Pseudomonas aeruginosa, mycobacteria, fungi, bacteria, pathogens and tumor cells, which have better inhibit and kill ability.
D-tryptophan can be used for the synthetic of semi-synthetic antibiotics, for which pharmacological plays an important role for the side chain. The peptide bond is difficult to be β-lactam enzyme action, thus high stability, and has broad antibacterial spectrum, toxicity, hypoallergenic, rapid absorption, high blood concentrations of the drug long duration.
Project Standards Appearance  white or slightly yellow crystalline powder
Content 99.0%~101.0%
Specific rotation [α] D20 + 30.5 °~+ 32.5 °
Transmittance ≥95.0%
Acidity PH 5.5~6.4
Loss on drying ≤0.2%
Residue on ignition ≤0.1%
Chloride [Cl-] ≤0.02%
Sulphate [SO42-] ≤0.02%
Ammonium [NH4 +] ≤0.02%
Heavy metals [Pb] ≤10ppm
Ferric [Fe] ≤10ppm
Arsenic salt [As2O3] ≤1ppm
Other amino acids compliance
Application An important nutrient, niacin is used as the control agent Medicine
Production method: D-tryptophan as raw material, chloroacetic anhydride was added under cooling state after polishing sulfuric acid in ice water, filtered and recrystallized from water, and finally treatment with carboxypeptidase trypsin to remove L-type, acidified with acetic acid, ethanol recrystallization refining.
References href="javascript:void(0);"/font>
References Fujita, Yukihiro, et al. "Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo." American Journal of Physiology Endocrinology & Metabolism 296.3(2009):E473.
Bacchus, W, W. Weber, and M. Fussenegger. "Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species." Metabolic Engineering 15.1(2013):144.
Chemical Properties white powder
Uses An essential amino acid found in naturally produced pedtides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.
Uses An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.
Definition ChEBI: The D-enantiomer of tryptophan.
General Description White solid.
Air & Water Reactions Slightly soluble in water.
Reactivity Profile Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard Flash point data are not available for D(+)-Tryptophan, but D(+)-Tryptophan is probably combustible.
 
D(+)-Tryptophan Preparation Products And Raw materials
Raw materials DL-Tryptophan-->Chloroacetic anhydride

 

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